Summary.Studies on the oxygen consumption of the isolated frog skin during active transport of sodium are reported, and the following results were obtained:1. In most cases, the total oxygen consumption is less than 1 equivalent per equivalent of sodium transported.2. The amount of oxygen consumed by the skin during transport of sodium exceeds that consumed when no transport occurs.3. The net consumption of oxygen, equal to the oxygen consumption during transport minus that in the absence of transport, bears a constant ratio to the amount of transported sodium, being 1/4–1/5 equivalent for each equivalent of sodium transported.4. This ratio is independent of oxygen tension and of treatment with posterior pituitary hormone, and the same ratio is found with skins from both Rana temporaria, Rana esculenta and Bufo buf
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