The roles of the SWI/SNF complex in cancer

摘要

The mammalian switch sucrose non-fermentable (SWI/SNF) chromatin remodeling complex, also known as the BRG1/BRM-associated factor (BAF) complex, is a key epigenetic modifier that orchestrates chromatin compaction and accessibility for gene transcription in an adenosine triphosphate–dependent manner. It thereby enables DNA replication and accessibility for selective gene transcription, DNA repair, and recombination