Accumulating evidence suggests that host cells can induce local and systemic responses following cancer therapy to stimulate tumour progression. This led Nolan et al. to hypothesize that injury to healthy tissues resulting from off-target radiation may predispose to subsequent metastatic outgrowth. To test their idea, the authors used a mouse model of acute radiation exposure to the lung within the setting of breast cancer metastasis to reveal that radiation can create a pro-metastatic lung microenvironment, an effect mediated by neutrophils.
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