Bioactive lipids are involoved in signalling in every cell of organism by affecting cell function and regulation. Few lipid-derived bioactive molecules, except eicosanoids, had been described. However, studies conducted in the last 15 to 20 years have shown that fatty acids, fatty acid derivatives, and other lipid molecules have a wide range of biological functions. Bioactive lipids come in a wide range of structural forms, from straightforward saturated fatty acids to intricate compounds generated from different omega-3 and omega-6 Polyunsaturated Fatty Acids (PUFA) and sphingosine. The different phospholipases and phospholipid kinases, which are themselves activated by a variety of signal transducing receptors, produce several bioactive lipids as a result of their actions.
展开▼