Cellular therapies are poised to transform the field of medicine by restoring dysfunctional tissues and treating various diseases in a dynamic manner not achievable by conventional pharmaceutics. Spanning various therapeutic areas inclusive of cancer, regenerative medicine, and immune disorders, cellular therapies comprise stem or non-stem cells derived from various sources. De -spite numerous clinical approvals or trials underway, the host immune response presents a critical impediment to the widespread adoption and success of cellu-lar therapies. Here, we review current research and clinical advances in immuno-modulatory strategies to mitigate immune rejection or promote immune tolerance to cellular therapies. We discuss the potential of these immunomodu-latory interventions to accelerate translation or maximize the prospects of im-proving therapeutic outcomes of cellular therapies for clinical success.
展开▼
