Mutations of TMC1 cause deafness by disrupting mechanoelectrical transduction

摘要

Objective: Mutations of transmembrane channel-like 1 gene (TMC1) can cause dominant (DFNA36) or recessive (DFNB7/B11) deafness. In this article, we describe the characteristics of DFNA36 and DFNB7/ B11 deafness, the features of the Tmc1 mutant mouse strains, and recent advances in our understanding of TMC1 function.