Radiosensitization by Radiofrequency Fields is Correlated with Micronucleus Yield and Proliferative Index

摘要

Radiofrequency fields have been shown to potentiate the inactivating effects of ionizing radiation. Using four human cell lines: MeWo (melanoma), Be11 (melanoma), DU145 (prostate cancer), and L132 (normal lung fibroblasts), it is demonstrated that cellular radiosensitization by 100- and 1000-Hz amplitude modulated radiofrequency fields is correlated with micronucleusyield (DNA damage) and binucleation index (proliferation). Cells that were more radiosensitized by radiofrequency fields were found to show increased levels of micronucleus yield. A high level of radiosensitization by the 100-Hz modulated field was correlated with increased proliferative index, while an elevated binucleation index was linked to minimal radiosensitization by the 1000-Hz modulated field. These findings suggest that radiofrequency fields can interfere with cellular processing of ionizing radiation-induced DNA damage and cell cycle progression, and may have significant implications in radiotherapy, radiation protection, and wound healing in preoperative radiotherapy.