Circulating Branched-Chain Amino Acids, Incident Cardiovascular Disease, and Mortality in the African American Study of Kidney Disease and Hypertension

摘要

Branched-chain amino acids (BCAAs), that is, leucine, isoleucine, and valine, are essential amino acids involved in glucose regulation, immunity, and cell signaling. Excessive circulating BCAAs predict type 2 diabetes and subsequent cardiovascular disease (CVD) in the general population. Chronic kidney disease (CKD) alters circulating metabolites and is a strong CVD risk factor. We leveraged the AASK trial (African American Study of Kidney Disease and Hypertension) to evaluate BCAAs’ cardiovascular effects in CKD outside the context of diabetes