Detection of twoiTaq/iI polymorphisms in the VTR region of the humaniHRAS1/ioncogene

摘要

Restriction enzyme analysis of the variable tandem repetition (VTR) region of the human HRAS1 oncogene revealed two Taql polymorphisms. The first polymorphism overlaps that detected with MspliHpaW restriction enzymes and is due to a variable number of repeat units which form the VTR region at the 3’ end of the oncogene. The second polymorphism appears to be due to two new Taql restriction sites created within the VTR region itself. This novel polymorphism was detected in 26 of 145 human DNA samples and was found to segregate in a Mendelian fashio