WNT2b Activates Epithelial-mesenchymal Transition Through FZD4: Relevance in Penetrating Crohn's Disease

摘要

Background and Aims: Epithelial-mesenchymal transition [EMT] has been related to fibrosis and fistula formation, common complications associated with Crohns disease [CD]. The WNT signalling pathway mediates EMT, and specific WNT/FZD interactions have been related to the activation of this process in several diseases. We aim to analyse the relevance of EMT and WNT ligands and receptors in the penetrating behaviour of CD.