HSP70‐Hom NcoI POLYMORPHISM AND HLA‐ASSOCIATIONS IN THE FINNISH POPULATION AND IN PATIENTS WITH ANKYLOSING SPONDYLITIS OR REACTIVE ARTHRITIS

摘要

SUMMARYTheNcoI polymorphism of theHSP70‐Homgene was investigated in the Finnish population and in two HLA‐B27‐associated autoimmune diseases. The twoHSP70‐Homalleles were shown to be strongly associated to some specific HLA‐B/DR haplotypes in random Finnish population and the segregation of the alleles as a part of these haplotypes was confirmed in 18 families. In addition, theHSP70‐Homalleles of 31 patients with ankylosing spondylitis (AS) and 38 with reactive arthritis (ReA) were compared with each other and with 56 unrelated healthy HLA‐B27 positive individuals. The results indicated that theHSP70‐Hompolymorphic variation is not connected independently to the different pathogenesis of AS and ReA, as no statistically significant differences between the patient groups and/or controls could be found. TheHSP70‐Homstatus was investigated also in 28 homozygous HLA typing cells and when compared with previously published results ofHSP70‐1andHSP0‐2polymorphisms, it appeared that these three MHC Class‐III linkedHSP70genes segregated in fix