Localization of a β-crystallin gene, HuβA3/A1 (gene symbol:iCRYB1/i), to the long arm of human chromosome 17

摘要

We have assigned a human β-crystallin gene, HuβA3/A1 (gene symbol: CRYB1), to chromosome 17 using a panel of 19 human-hamster somatic cell hybrids and blot-hybridization analysis of cell hybrid DNA. Positive probe-hybridization signal was detected in a hybrid that had lost the short arm of human chromosome 17 but retained the long arm, translocated to a hamster chromosome. In addition, in situ hybridization analysis of metaphase chromosome spreads of this cell line suggested that the most probable location for CR YB1 is on the long arm of chromosome 17, in the region q2