Diastereoselective Synthesis of Chiral Bicyclic Phosphoramides Derived from (S)-2-(Anilinomethyl) Pyrrolidine

摘要

The diastereoselectivity of the chiral bicyclic phosphoramide synthesis can be improved under certain conditions of temperature and degree of polarity of the solvent. Measured diastereomer ratio (exo-isomer:endo-isomer) enhanced from (1.00:1.00) to (1.00:1.44) in favourable cases. This enhancement in the diastereoselectivity is highly relevant to the development of asymmetric synthesis, where chiral bicyclic phosphoramides are used as catalysts.