Localization of the human X-linked gene for chronic granulomatous disease to the mouse X chromosome: implications for X-chromosome evolution

摘要

The gene encoded at the human X-linked chronic granulomatous disease locus (cytochrome b245 β subunit) has been mapped to the mouse X chromosome using an interspecific Mus domesticus × M. spretus cross. The localization of this gene provides detailed information on one of the proposed ancestral breakpoints that account for the divergent evolution of the mouse and human X chromosome