Infection caused by Novel Coronavirus has been declared a pandemic and is spreading across 213 countries and territories around the world with severe implications. The present paper tries to review the relationship of SARS-Cov-2 infection with ACE2 expression, gene polymorphism and cardiovascular malfunctions, hypertension and type-2 diabetes. The paper highlights the fact that since ACE2 gene polymorphisms tend to be population specific, screening of ACE2 polymorphisms in diverse population groups across geographies could be beneficial in evaluating the severity to SARS-Cov-2 infection.
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