Successful unrelated donor cord blood transplantation for adult sickle cell disease and Hodgkin lymphoma.

摘要

Unrelated donor cord blood (CB) offers an alternative hematopoietic stem cell (HSC) source for racial and ethnic minorities who lack suitable sibling donors and are under-represented in unrelated volunteer donor registries. We report the case of a 22-year-old African-American woman with a history of sickle cell disease (SCD) complicated by pain crises, cerebrovascular disease, nephropathy, chronic leg ulcers and cholelithiasis. She was also diagnosed with stage IA nodular sclerosis Hodgkin lymphoma (HL) in 1999, and was placed in CR with four cycles of combination chemotherapy (COPP/ABV).