Pre-emptive granulocyte transfusions enable allogeneic hematopoietic stem cell transplantation in pediatric patients with chronic infections.

摘要

Granulocyte transfusions (GTX) have been previously reported to be a therapeutic modality for patients with severe infections in prolonged aplasia.1"3 A persistent, poorly controlled bacterial or fungal infection prior to allogeneic HSCT (allo-HSCT) is a severe risk factor for morbidity and mortality. It was our hypothesis that pre-emptive GTX can enable patients to undergo a lifesaving allo-HSCT. Therefore, we developed a protocol for patients with persistent, poorly controlled infections to undergo a HCT under the coverage of GTX. Here we report our experience with three children who underwent such a procedure.