Induction of delivery by mifepristone and misoprostol in termination of pregnancy and intrauterine fetal death: 2nd and 3rd trimester induction of labour.

摘要

Misoprostol is used as off-label medication for pregnancy termination. Mifepristone given prior to misoprostol seems beneficial in termination of pregnancy (ToP), but effectiveness in intrauterine fetal death (IUFD) needs to be further evaluated [1-6]. The objective of this pilot was to describe the effectiveness of combined mifepristone-misoprostol regimen for labour induction in ToP and IUFD. We collected data from patients in whom labour was induced due to ToP in 2nd trimester or IUFD in 2nd and 3rd trimester between 2007 and 2010. The local protocol in the 2nd trimester consisted of 200 mg mifepristone orally, and 36 h later 200 mug misoprostol vaginally every 3 h. Third trimester induction for IUFD was performed with 200 ug misoprostol vaginally, 36 h after 200 mg mifepristone, every 6 h. Data were collected on demographics, obstetric history, delivery and complications.