Multiple myeloma with concomitant JAK2-positive essential thrombocythemia post-successful autologous peripheral blood hematopoietic stem cell transplant.

摘要

The case that follows is to our knowledge the first report of successful cytokine-stimulated mobilization and collection of PBSCs followed by autologous peripheral blood hematopoietic stem cell transplant for an aggressive hematologic malignancy in a patient with a concomitant chronic myeloproliferative neoplasm. In 2007, a 51-year-old man developed large extremity hematomas without precipitating trauma. Complete blood count revealed a pit count of 716000 without anemia or leukocytosis. Coagulation studies showed a low ristocetin cofactor of 43% and low von Willebrand Ag of 59% with normal multimer distribution. BM biopsy was performed, given suspicion of a myeloproliferative neoplasm, and it showed 60% cellularity with megakaryocytic hyperplasia and clustering with no increased blasts.