Allergy transfer with hematopoietic cell transplantation from an unrelated donor.

摘要

Allergy may be transferred from an allergic donor to a non-allergic recipient of hematopoietic cell transplantation (reviewed by Khan et al.). It is generally thought that this is due to the adoptive transfer of allergen-specific B cells (differentiating into IgE plasma cells) or allergen-specific T cells (helping allergen-specific B cells to differentiate into IgE plasma cells). This' is supported by reports that typically detected the presence of IgE for the same allergen in the donor and in the recipient post transplant.1 There is also an alternative explanation for the acquisition of allergy through hematopoietic cell transplantation from an allergic donor: transfer of hematolymphatic system prone to support differentiation of B cells into IgE plasma cells in general.