High efficiency enrichment of low-abundance peptides by novel dual-platform graphene@SiO2@PMMA

摘要

For the first time, dual-platform graphene@SiO2@poly(methyl methacrylate) (PMMA) material was synthesized, and successfully applied to efficiently enrich low-abundance peptides for mass spectrometry analysis. Since its discovery, graphene has attracted much attention due to its extraordinary electrical, thermal and mechanical properties arising from its unique structure of a 2D single layer of carbon atoms that packs in a hexagonal fashion. Great effort has recently been devoted to the development of graphene-based composites by integrating graphene nanosheets with other materials into various multifunctional materials and/or nanodevices for applications in various fields, including field-effect devices, chemical and biological sensors, energy-storage materials, high-performance polymer composites, and electrocatalysis. Additionally, as a result of its structural features and its mechanical and thermal properties, graphene has shown great potential in the field of analytical chemistry. For example, graphene has been utilized as a novel matrix in mass spectrometry and electrochemistry. In analytical chemistry, the design and synthesis of graphene composite materials for the extraction and enrichment of analytes have become research hot-spots.