A Mild and Versatile Method for the Synthesis of Alkyl Ethers from Methoxymethyl Ethers and Application to the Preparation of Sterically Crowded Ethers

摘要

A mild and divergent route for the synthesis of alkyl ethers from methoxymethyl (MOM) and methoxyethyl (ME) ether derivatives via pyri-dinium-type salt intermediates has been developed. The addition of organocuprates to the salts afforded the corresponding alkyl ethers, including highly crowded ones, in high yields even in the presence of acid- or base-sensitive functional groups.