Intact protein LC-MS for pharmacokinetics

摘要

Biography: John Kellie is currently a GlaxoSmithKline (GSK) fellow in the Bioanalysis, Immunogenicity, and Biomarkers group at GSK. John received his BSc in Biochemistry from Indiana University (USA) and his PhD in Chemistry from Northwestern University (USA) studying under Dr Neil Kelleher. He was a postdoctoral scientist at Eli Lilly and Company, where he developed methods for intact protein quantitation of a Parkinson's Disease biomarker from human brain tissue. At GSK, John utilizes mass spectrometry for development of novel bioanalytical methods for biotherapeutic and protein quantitation from pre-clinical and clinical samples, with a focus on intact protein and large mass quantitation for pharmacokinetics, catabolism, biotransformation and product quality attribute support. John Kellie speaks to the Interna-tionalJournal of Pharmacokinetics about intact protein LC-MS for pharmacokinetic application.