Advances in Oncology: Safety of chemotherapy in pregnancy

摘要

FA Physicians were reluctant to give chemotherapy during pregnancy because the long-term safety outcome was uncertain, especially with regard to the child. The prognosis was thought to be better when pregnancy was interrupted. Avoidance of chemotherapy during pregnancy resulted in 3 situations. First, there were terminations of pregnancy. Second, maternal treatment was delayed until the baby was viable. After the baby was born, the mother would then start the chemotherapy. Third, physicians might choose not to start chemotherapy during pregnancy and then induce labor early, so that chemotherapy could be started after delivery. In my experience, the long-term consequences of prematurity have long been underestimated. The interdisciplinary teams that decided on the course of management usually included oncologists, surgeons, and gynecologists; obstetricians and perinatologists were generally not consulted. A decision might be made to induce delivery at 32 weeks, when the baby was thought to be viable. However, even at 32 weeks, there may be important long-term consequences of premature delivery.