Genetics, Mucosal Inflammation, and the Environment in Post-Infectious Chronic Gut Syndromes

摘要

It is known that infection may trigger post-infectious chronic gut syndromes for example, post-infectious irritable bowel syndrome and post-infectious functional dyspepsia. This sequence of events is likely dependent upon a myriad of other host and environmental factors and an inherent inflammatory response of the gut mucosa to pathogens, which may be regulated by the genetic background. This review topic aims to unravel genetic influences on host response, which lead to differing clinical outcomes in enteric infection preceding chronic gut syndromes.