Development and Evaluation of a Method to Correct Misinterpretation of Clinical Trial Results With Long-term Survival

摘要

IMPORTANCE In immune checkpoint inhibitor (ICI) trials, long tails and crossovers in survival curves-which violate the proportional hazards (PH) assumption-are commonly observed, making cure or restricted mean survival time models preferable for analysis of ICI survival data. Cox PH analysis, however, still appears in major medical journals, leading to potential misinterpretation of clinical significance.