Comparison of the Prevalence of Pathogenic Variants in Cancer Susceptibility Genes in Black Women and Non-Hispanic White Women With Breast Cancer in the United States

Domchek Susan M.; Yao Song; Chen FeiHu ChunlingHart Steven N.Goldgar David E.Nathanson Katherine L.Ambrosone Christine B.Haiman Christopher A.Couch Fergus J.Polley Eric C.Palmer Julie R.

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Comparison of the Prevalence of Pathogenic Variants in Cancer Susceptibility Genes in Black Women and Non-Hispanic White Women With Breast Cancer in the United States

机译：在美国，黑人妇女和非西班牙裔白人妇女患有乳腺癌的癌症易感基因中病原变异的患病率在美国的患病率

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IMPORTANCE The prevalence of germline pathogenic variants (PVs) in cancer susceptibility genes in US Black women compared with non-Hispanic White women with breast cancer is poorly described.

机译：与非西班牙裔白人妇女相比，美国黑人妇女的癌敏感性基因中种系致病变异（PV）的流行率很差。

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《JAMA oncology.》 |2021年第7期|1045-1050|共6页
作者
Domchek Susan M.; Yao Song; Chen FeiHu ChunlingHart Steven N.Goldgar David E.Nathanson Katherine L.Ambrosone Christine B.Haiman Christopher A.Couch Fergus J.Polley Eric C.Palmer Julie R.;
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作者单位

Univ Penn, Perelman Sch Med, Basser Ctr BRCA, Abramson Canc Ctr, 3400 Civ Ctr Blvd, Philadelphia;

Roswell Park Comprehens Canc Ctr, Dept Canc Prevent & Control, Buffalo, NY USA;

Mayo Clin, Rochester, MN USAUniv Utah, Huntsman Canc Inst, Salt Lake City, UT USABoston Univ, Slone Epidemiol Ctr, Boston, MA 02215 USAUniv Southern Calif, Keck Sch Med, Los Angeles, CA 90007 USA;

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正文语种英语
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关键词
Cancer-Predisposing Gene; United States; variantsBreast CancerPrevalence;

机译：癌化基因;美国;变体癌症;

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Comparison of the Prevalence of Pathogenic Variants in Cancer Susceptibility Genes in Black Women and Non-Hispanic White Women With Breast Cancer in the United States

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