RS4651 suppresses lung fibroblast activation via the TGF-beta 1/SMAD signalling pathway

Li Shirong; Xu Anjian; Li Yanmeng; Tan Chunting; Regina Giuseppe La; Silvestri Romano; Wang Haoyan; Qi Wenjie

首页> 外文期刊>European Journal of Pharmacology: An International Journal >RS4651 suppresses lung fibroblast activation via the TGF-beta 1/SMAD signalling pathway

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RS4651 suppresses lung fibroblast activation via the TGF-beta 1/SMAD signalling pathway

机译：RS4651通过TGF-Beta 1 / Smad信号通路抑制肺成纤维细胞活化

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Background: Idiopathic pulmonary fibrosis (IPF) is a progressive disease resulting in respiratory failure with no efficient treatment options. We investigated the protective effect of RS4651 on pulmonary fibrosis in mice and the mechanism.

机译：背景：特发性肺纤维化（IPF）是一种进展性疾病，导致呼吸衰竭，没有有效的治疗选择。我们研究了RS4651对小鼠肺纤维化的保护作用及其机制。

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来源
《European Journal of Pharmacology: An International Journal》 |2021年第1期|共10页
作者
Li Shirong; Xu Anjian; Li Yanmeng; Tan Chunting; Regina Giuseppe La; Silvestri Romano; Wang Haoyan; Qi Wenjie;
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作者单位

Capital Med Univ Beijing Friendship Hosp Dept Infect Dis Beijing 100050 Peoples R China;

Capital Med Univ Beijing Friendship Hosp Expt Ctr Liver Res Ctr Natl Clin Res Ctr Digest Dis;

Capital Med Univ Beijing Friendship Hosp Expt Ctr Liver Res Ctr Natl Clin Res Ctr Digest Dis;

Capital Med Univ Beijing Friendship Hosp Dept Resp Med Beijing 100050 Peoples R China;

Sapienza Univ Rome Lab Inst Pasteur Italy Dept Drug Chem &

Technol Cenci Bolognett Fdn Piazzale;

Sapienza Univ Rome Lab Inst Pasteur Italy Dept Drug Chem &

Technol Cenci Bolognett Fdn Piazzale;

Capital Med Univ Beijing Friendship Hosp Dept Resp Med Beijing 100050 Peoples R China;

Capital Med Univ Beijing Friendship Hosp Dept Infect Dis Beijing 100050 Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
Pulmonary fibrosis; RS4651; alpha-SMA; TGF-beta 1; SMAD7;

机译：肺纤维化;RS4651;α-SMA;转化生长因子β1;SMAD7;

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1. Increased Cthrcl Activates Normal Fibroblasts and Suppresses Keloid Fibroblasts by Inhibiting TGF-β/Smad Signal Pathway and Modulating YAP Subcellular Location [J] . Meng-jie ZHAO, Si-yuan CHEN, Xiao-ying QU, 当代医学科学(英文) . 2018,第005期
2. PTPL1 suppresses lung cancer cell migration via inhibiting TGF-β1-induced activation of p38 MAPK and Smad 2/3 pathways and EMT [J] . Ning Zhu, Gulinuer Wumaier, Sheng-qing Li, 中国药理学报：英文版 . 2021,第008期
3. Bcl6 Suppresses Cardiac Fibroblast Activation and Function via Directly Binding to Smad4 [J] . Jian NI, Qing-qing WU, Hai-han LIAO, 当代医学科学(英文) . 2019,第004期
4. TGF-beta Upregulated Mitochondria Mass through the SMAD2/3 - C/EBP beta - PRMT1 Signal Pathway in Primary Human Lung Fibroblasts [J] . Sun Qingzhu, Fang Lei, Tang Xuemei, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2019,第1期

机译：TGF-β通过Smad2 / 3 - ＆gt上调线粒体质量。 C / EBP Beta - ＆原发性人肺成纤维细胞中的PRMT1信号途径
5. LOXL2, a copper-dependent monoamine oxidase, activates lung fibroblasts through the TGF-beta/Smad pathway [J] . Wen Xiaohong, Liu Yuan, Bai Yu, International journal of molecular medicine . 2018,第6期

机译：LOX12，依赖于铜依赖性单胺氧化酶，通过TGF-β/ Smad途径激活肺成纤维细胞
6. Asiaticoside suppresses collagen expression and TGF-beta/Smad signaling through inducing Smad7 and inhibiting TGF-betaRI and TGF-betaRII in keloid fibroblasts. [J] . Tang B, Zhu B, Liang Y, Archives of dermatological research. . 2011,第8期

机译：积雪草苷通过在瘢痕loid成纤维细胞中诱导Smad7并抑制TGF-betaRI和TGF-betaRII来抑制胶原蛋白表达和TGF-beta / Smad信号传导。
7. Signaling Pathways Involved in Proteinase-Activated Receptor_1-Induced Proinflammatory and Profibrotic Mediator Release Following Lung Injury [C] . PAUL F. MERCER, XIAOLING DENG, RACHEL C. CHAMBERS Meeting on Cell Signaling World: Signal Transduction Pathways as Therapeutic Targets . 2007

机译：信号通路参与蛋白酶激活的受体_1诱导肺损伤后促炎性和纤维化介质的释放。
8. TGF-beta/Smad1 signaling defines a subset of scleroderma fibroblasts. [D] . Morris, Erin E. 2009

机译：TGF-beta / Smad1信号传导定义了硬皮病成纤维细胞的一个子集。
9. Transcriptional activation of the murine Muc5ac mucin gene in epithelial cancer cells by TGF-beta/Smad4 signalling pathway is potentiated by Sp1. [O] . Nicolas Jonckheere, Maria Van Der Sluis, Amélie Velghe, 2004

机译：Sp1增强了TGF-beta / Smad4信号通路在上皮癌细胞中对鼠Muc5ac黏蛋白基因的转录激活。
10. Activating transcription factor 3 (ATF3) regulates cell growth, apoptosis, invasion and collagen synthesis in keloid fibroblast through transforming growth factor beta (TGF-beta)/SMAD signaling pathway [O] . Xue-Ming Wang, Xiu-Mei Liu, Yuting Wang, 2020

机译：激活转录因子3（ATF3）通过转化生长因子β（TGF-β）/ Smad信号通路来调节瘢痕疙瘩成纤维细胞中的细胞生长，凋亡，侵袭和胶原合成
11. Inhibition of the TGF-Beta Tumor Suppression Pathway Through Repression of Smad Dependent Transcription [R] . Pan, D. , Luo, K. 2004

机译：通过抑制smad依赖性转录抑制TGF-β肿瘤抑制途径

RS4651 suppresses lung fibroblast activation via the TGF-beta 1/SMAD signalling pathway

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