Endobronchial Ultrasound-guided Transbronchial Needle Aspiration for Systematic Nodal Staging of Lung Cancer in Patients with NO Disease by Computed Tomography and Integrated Positron Emission Tomography-Computed Tomography

摘要

Rationale: Data regarding the sensitivity of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) for staging of lung cancer in patients with radiographic NO disease is scant and inconsistent. With increasing use of nonoperative ablative therapies, studies focusing on the performance characteristics of EBUS-TBNA in this population are important.Objectives: To evaluate the sensitivity and negative predictive value (NPV) of EBUS-TBNA in patients with non-small cell lung cancer and radiographic NO disease both by computed tomography (CT) and positron emission tomography (PET)-CT.Methods: This was a retrospective review of EBUS-TBNA performed for lung cancer staging at two major academic centers from 2009 to 2014. Patients with radiographic NO disease (lymph nodes [LN] =￡ 1 cm in the short axis and maximum standardized uptake value =￡ 2.5 by PET-CT) were included. Primary outcome was sensitivity and NPV of EBUS-TBNA.