Synthesis, Antibacterial Activity, and Docking Studies of 1,2,3‐triazole‐tagged Thieno[2,3‐ dd ]pyrimidinone Derivatives

摘要

> Novel (1‐(substituted phenyl)‐1 H ‐1,2,3‐triazol‐4‐yl)methyl‐2‐(4‐oxo‐5,6,7,8‐tetrahydrobenzo[1,2]thieno[2,3‐ d ]pyrimidin‐3(4 H )‐yl)acetate derivatives were synthesized. All the compounds showed significant antibacterial activity against Gram‐negative ( Escherichia coli and Klebsiella pneumonia ) and Gram‐positive ( Bacillus subtilis and Bacillus cereus ) bacteria. Particularly, (1‐(3‐nitrophenyl)‐1 H ‐1,2,3‐triazol‐4‐yl)methyl‐2‐(4‐oxo‐5,6,7,8‐tetrahydrobenzo[1, 2]thieno[2,3‐ d ]pyrimidin‐3(4 H )‐yl)acetate was found to be most potent against E.?coli , K.?pneumonia , and B.?subtilis with MIC 25?μg/ml . Molecular docking was also performed on purine riboswitch of B.?subtilis and thiamine pyrophosphate riboswitch of E.?coli .