Multicomponent Training Changes Blood Pressure and Redox Status in Older Women: Influence of β_2 Adrenergic Receptor Haplotypes

摘要

The β_2 adrenergic receptor (pVAR) plays an important role in vascular smooth muscle. However, the interaction between Argl6Gly and Gln27Glu β_2-AR polymorphisms, and exercise training has not yet been established. This study evaluated the influence of these β_2-AR polymorphisms on body composition, aerobic capacity, blood pressure, lipid profile, nitric oxide, and redox status at baseline and in response to an exercise program in women aged 50-79 years. Genotype and haplotypes were analyzed in association with the previously mentioned variables before and after the multicomponent training (12 weeks, 2 sessions/week, 90 min/session, and exercise intensity between 13 and 15 on the Borg scale). Individuals who carry β_2-AR Argl6Arg/Gln27Gln genotypes presented more improvements in blood pressure, body composition, aerobic capacity, and redox status in response to a multicomponent training program compared with individuals who do not carry this haplotype. In some years, the genetic profile may be used to predict which exercise program can induce more health benefits for each person.