Mean platelet volume predicts prognosis in patients with diffuse large B‐cell lymphoma

摘要

Abstract To determine the prognostic value of baseline mean platelet volume (MPV) in diffuse large B‐cell lymphoma (DLBCL) patients. We retrospectively analyzed 161 DLBCL patients who received R‐CHOP chemotherapy. The associations between MPV and clinicopathological factors were assessed. A low MPV (MPV ≤ 9.1 fl, cut‐off was calculated by receiver operating characteristics) was not associated with any other clinicopathological factors. Patients with MPV?≤?9.1?fl experienced a shorter progression‐free survival (PFS) (2‐year PFS rate, 60.6% vs 84.0%, P ?=?0.003) and overall survival (OS) (2‐year OS rate, 70.4% vs 87.9%, P ?=?0.030), compared with those with MPV??9.1?fl. The multivariate analysis demonstrated that MPV?≤?9.1?fl was an independent prognostic factor of OS (Hazard Ratio [HR]?=?0.588, P ?=?0.045) and PFS (HR?=?0.456, P ?=?0.010). Therefore, we demonstrated that low baseline MPV is an independent prognostic marker of poor outcome in patients with DLBCL.