Inhibition of LRRK2 restores parkin-mediated mitophagy and attenuates intervertebral disc degeneration

Lin Jialiang; Zheng Xuanqi; Zhang Zengjie; Zhuge Jinru; Shao Zhenxuan; Huang Chongan; Jin Jie; Chen Ximiao; Chen Yu; Wu Yaosen; Tian Naifeng; Sun Liaojun; Gao Weiyang; Zhou Yifei; Wang Xiangyang; Zhang Xiaolei

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Inhibition of LRRK2 restores parkin-mediated mitophagy and attenuates intervertebral disc degeneration

机译：LRRK2抑制恢复Parkin介导的乳白质和衰减椎间盘变性

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Objective: To elucidate the role of LRRK2 in intervertebral disc degeneration (IDD) as well as its mitophagy regulation mechanism.

机译：None

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来源
《Osteoarthritis and cartilage》 |2021年第4期|共13页
作者
Lin Jialiang; Zheng Xuanqi; Zhang Zengjie; Zhuge Jinru; Shao Zhenxuan; Huang Chongan; Jin Jie; Chen Ximiao; Chen Yu; Wu Yaosen; Tian Naifeng; Sun Liaojun; Gao Weiyang; Zhou Yifei; Wang Xiangyang; Zhang Xiaolei;
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作者单位

Wenzhou Med Univ Dept Orthopaed Affiliated Hosp 2 109 West Xueyuan Rd Wenzhou 325027 Zhejiang;

Wenzhou Med Univ Dept Orthopaed Affiliated Hosp 2 109 West Xueyuan Rd Wenzhou 325027 Zhejiang;

Zhejiang Univ Dept Orthopaed Affiliated Hosp 2 Sch Med Hangzhou Zhejiang Peoples R China;

Wenzhou Med Univ Yuying Childrens Hosp 109 West Xueyuan Rd Wenzhou 325027 Zhejiang Peoples R;

Wenzhou Med Univ Dept Orthopaed Affiliated Hosp 2 109 West Xueyuan Rd Wenzhou 325027 Zhejiang;

Wenzhou Med Univ Dept Orthopaed Affiliated Hosp 2 109 West Xueyuan Rd Wenzhou 325027 Zhejiang;

Wenzhou Med Univ Dept Orthopaed Affiliated Hosp 2 109 West Xueyuan Rd Wenzhou 325027 Zhejiang;

Guilin Med Coll Dept Orthopaed Affiliated Hosp Guilin Guangxi Peoples R China;

Wenzhou Med Univ Dept Orthopaed Affiliated Hosp 2 109 West Xueyuan Rd Wenzhou 325027 Zhejiang;

Wenzhou Med Univ Dept Orthopaed Affiliated Hosp 2 109 West Xueyuan Rd Wenzhou 325027 Zhejiang;

Wenzhou Med Univ Dept Orthopaed Affiliated Hosp 2 109 West Xueyuan Rd Wenzhou 325027 Zhejiang;

Wenzhou Med Univ Dept Orthopaed Affiliated Hosp 2 109 West Xueyuan Rd Wenzhou 325027 Zhejiang;

Wenzhou Med Univ Dept Orthopaed Affiliated Hosp 2 109 West Xueyuan Rd Wenzhou 325027 Zhejiang;

Wenzhou Med Univ Dept Orthopaed Affiliated Hosp 2 109 West Xueyuan Rd Wenzhou 325027 Zhejiang;

Wenzhou Med Univ Dept Orthopaed Affiliated Hosp 2 109 West Xueyuan Rd Wenzhou 325027 Zhejiang;

Wenzhou Med Univ Dept Orthopaed Affiliated Hosp 2 109 West Xueyuan Rd Wenzhou 325027 Zhejiang;

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正文语种 eng
中图分类骨科学（运动系疾病、矫形外科学）;
关键词
LRRK2; Mitochondria-dependent apoptosis; Mitophagy; Intervertebral disc degeneration;

机译：LRRK2;线粒体依赖性细胞凋亡;mitophy;椎间盘变性;

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专利

1. Protective effect of estrogen against intervertebral disc degeneration is attenuated by miR-221 through targeting estrogen receptor α [J] . Bin Sheng, Youchao Yuan, Xiangyang Liu, 生物化学与生物物理学报：英文版 . 2018,第004期
2. 3D assessment of intervertebral disc degeneration in zebrafish identifies changes in bone density that prime disc disease [J] . Erika Kague, Francesco Turci, Elis Newman, 骨研究：英文 . 2021,第004期
3. Relationship between Facet Joint Asymmetry and Adjacent Intervertebral Disc Degeneration in Lumbar Disc Herniation [J] . Shenghui Huang 生物科学与医学（英文） . 2020,第011期
4. Effects of acupuncture on expression of VEGF, PLA2 and PGE2 and extracellular matrix collagen and metabolic enzymes in the intervertebral disc of rats with cervical disc degeneration [J] . Sun Wei-Qiang, Zhang Guang-Zhi 海南医科大学学报(英文版) . 2019,第017期
5. Effects of acupuncture on expression of VEGF, PLA2 and PGE2 and extracellular matrix collagen and metabolic enzymes in the intervertebral disc of rats with cervical disc degeneration [J] . Sun Wei-Qiang, Zhang Guang-Zhi 海南医科大学学报（英文版） . 2019,第017期
6. Parkin-mediated mitophagy as a potential therapeutic target for intervertebral disc degeneration [J] . Zengjie Zhang, Tianzhen Xu, Jiaoxiang Chen, Cell death & disease. . 2018,第10期

机译：Parkin介导的椎间盘介导的椎间盘变性的潜在治疗靶标
7. Melatonin ameliorates intervertebral disc degeneration via the potential mechanisms of mitophagy induction and apoptosis inhibition [J] . Yu Chen, Yanqing Wu, Hongxue Shi, Journal of cellular and molecular medicine. . 2019,第3期

机译：褪黑素通过线粒体诱导和凋亡抑制的潜在机制改善椎间盘退变
8. Inhibition of EZH2 ameliorates cartilage endplate degeneration and attenuates the progression of intervertebral disc degeneration via demethylation of Sox-9 [J] . Chao Jiang, Qiang Guo, Yu Jin, EBioMedicine . 2019,第7期

机译：EZH2的抑制可改善软骨终板变性，并通过Sox-9脱甲基化减弱椎间盘退变的进程
9. Magnetic resonance elastography of intervertebral disc — A new biomarker for disc degeneration [C] . Cortes Daniel H., Magland Jeremy F., Wright Alexander C., Bioengineering Conference (NEBEC), 2012 38th Annual Northeast . 2012

机译：椎间盘磁共振弹性成像—椎间盘退变的新生物标记
10. Identifying the mechanism of decorin action in the intervertebral disc through an in vitro decorin over-expression system: Understanding the role of decorin in disc degeneration. [D] . Lundgren, Mary Elizabeth. 2010

机译：通过体外除芯蛋白过表达系统确定除芯蛋白在椎间盘中的作用机制：了解除芯蛋白在椎间盘退变中的作用。
11. Parkin-mediated mitophagy as a potential therapeutic target for intervertebral disc degeneration [O] . Zengjie Zhang, Tianzhen Xu, Jiaoxiang Chen, 2018

机译：Parkin介导的线粒体吞噬作为椎间盘退变的潜在治疗靶标
12. Parkin-mediated mitophagy as a potential therapeutic target for intervertebral disc degeneration [O] . Zengjie Zhang, Tianzhen Xu, Jiaoxiang Chen, 2018

机译：Parkin介导的椎间盘介导的椎间盘变性的潜在治疗靶标
13. Development of Ultrasound to Measure In-Vivo Dynamic Cervical Spine Intervertebral Disc Mechanics. [R] . Synder, B. 2016

机译：超声测量体内动态颈椎椎间盘力学的研究进展。

Inhibition of LRRK2 restores parkin-mediated mitophagy and attenuates intervertebral disc degeneration

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