TSA-catalyzed regioselective synthesis of medicinally important 4-aryl-substituted dihydropyrimidine derivatives fused to pyrazole and triazole scaffolds via an efficient and green Domino reaction

摘要

A novel class of medicinally important 4-arylsubstituted dihydropyrimidine derivatives fused to pyrazole and triazole scaffolds has been found which is obtained via a newly designed regioselective domino reaction using tungstate sulfuric acid (TSA) as a Bronsted acid recyclable catalyst. Throughout this tri-component tandem reaction, 4-aryl-substituted dihydropyrimidine derivatives fused to pyrazole and triazole moieties were regioselectively formed under environmentally benign solvent-free conditions with high yields. By this achievement, some novel potentially interesting biologically active products were synthesized via a green and eco-friendly procedure.