Nine years interval between first and second bone marrow transplantations and subsequent long-term survival-a case of acute myeloid leukemia with MLL-AF6 fusion gene

摘要

Prognosis of acute myeloid leukemia (AML) with t(6;11) (q27;q23), which results in production of MLL-AF6 fusion gene, is poor, and presence of t(6;11)(q27;q23) or MLL-AF6 mRNA is reported to be an independent risk factor of AML [1, 2]. In patients with high-risk AML, leukemia relapse post-allogeneic hematopoietic stem cell transplantation (allo-HSCT) is common and usually occurs within the first 3 years [3], making the late relapse rare. We present the first case of late relapse of AML with MLL-AF6 after allogeneic bone marrow transplantation (allo-BMT).