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首页> 外文期刊>Biochimica et biophysica acta: BBA: International journal of biochemistry, biophysics and molecular biololgy. Proteins and Proteomics >Comparative proteomic analysis of membrane microdomains isolated from two hyperlipidemic animal models
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Comparative proteomic analysis of membrane microdomains isolated from two hyperlipidemic animal models

机译:从两个高脂血症动物模型中分离的膜微区的比较蛋白质组学分析

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摘要

Hyperlipidemia is a common risk factor for the initiation and progression of cardiovascular diseases, affecting complex signaling pathways and leading to a fatal outcome in the most severe events. It has been proven that the non-ionic detergent insoluble membrane microdomains are enriched in signaling molecules, taking part in various essential physiological but also pathological processes. The aim of the present study was to demonstrate the comparable alteration of membrane signaling pathways produced by either genetically or diet induced hyperlipidemic stress.
机译:高脂血症是引发和发展心血管疾病的常见危险因素,会影响复杂的信号传导途径,并在最严重的事件中导致致命的后果。已经证明非离子去污剂不溶性膜微区富含信号传导分子,参与各种基本的生理过程以及病理过程。本研究的目的是证明通过遗传或饮食诱导的高脂血症应激所产生的膜信号通路的可比改变。

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