Celastrol Reverses Palmitic Acid-Induced Insulin Resistance in HepG2 Cells via Restoring the miR-223 and GLUT4 Pathway

Zhang Xue; Xue Xiao-Cheng; Wang Ying; Cao Fan-Fan; You Jun; Uzan Georges; Peng Bin; Zhang Deng-Hai

首页> 外文期刊>Canadian journal of diabetes >Celastrol Reverses Palmitic Acid-Induced Insulin Resistance in HepG2 Cells via Restoring the miR-223 and GLUT4 Pathway

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Celastrol Reverses Palmitic Acid-Induced Insulin Resistance in HepG2 Cells via Restoring the miR-223 and GLUT4 Pathway

机译：Celastrol通过恢复MiR-223和Glut4途径反转HepG2细胞中的棕榈酸诱导的胰岛素抗性

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Objectives: The natural triterpenoid compound celastrol ameliorates insulin resistance (IR) in animal models, but the underlying molecular mechanism is unclear. In this study, we investigated how celastrol regulates IR.

机译：目的：天然三萜化合物雷公藤红醇改善动物模型中的胰岛素抵抗（IR），但其潜在的分子机制尚不清楚。在这项研究中，我们研究了雷公藤红素如何调节IR。

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来源
《Canadian journal of diabetes》 |2019年第3期|共8页
作者
Zhang Xue; Xue Xiao-Cheng; Wang Ying; Cao Fan-Fan; You Jun; Uzan Georges; Peng Bin; Zhang Deng-Hai;
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作者单位

Secondary Mil Med Univ Shanghai Gongli Hosp Sino French Cooperat Cent Lab 207 Ju Ye Rd Shanghai;

Secondary Mil Med Univ Shanghai Gongli Hosp Dept Otolaryngol Shanghai Peoples R China;

Secondary Mil Med Univ Shanghai Gongli Hosp Sino French Cooperat Cent Lab 207 Ju Ye Rd Shanghai;

Secondary Mil Med Univ Shanghai Gongli Hosp Sino French Cooperat Cent Lab 207 Ju Ye Rd Shanghai;

Secondary Mil Med Univ Shanghai Gongli Hosp Sino French Cooperat Cent Lab 207 Ju Ye Rd Shanghai;

Hop Paul Brousse INSERM Lavoisier Bldg Villejuif France;

Secondary Mil Med Univ Shanghai Gongli Hosp Sino French Cooperat Cent Lab 207 Ju Ye Rd Shanghai;

Secondary Mil Med Univ Shanghai Gongli Hosp Sino French Cooperat Cent Lab 207 Ju Ye Rd Shanghai;

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原文格式 PDF
正文语种 eng
中图分类内分泌腺疾病及代谢病;
关键词
celastrol; glucose transporter 4 (GLUT4); insulin resistance; microRNA-223; palmitic acid;

机译：Celastrol;葡萄糖转运蛋白4（Glut4）;胰岛素抵抗;microRNA-223;棕榈酸;

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专利

1. Ellagic acid ameliorates oxidative stress and insulin resistance in high glucose-treated HepG2 cells via miR-223/keap1-Nrf2 pathway [J] . Ding Xiaoqin, Jian Tunyu, Wu Yuexian, Biomedicine & pharmacotherapy =: Biomedecine & pharmacotherapie . 2019,第期

机译：鞣酸可通过MIR-223 / Keap1-NRF2途径改善高葡萄糖处理的HEPG2细胞中的氧化应激和胰岛素抗性
2. Pterostilbene reverses palmitic acid mediated insulin resistance in HepG2 cells by reducing oxidative stress and triglyceride accumulation [J] . Free radical research . 2019,第1a12期

机译：通过降低氧化应激和甘油三酯积累，活体通过降低氧化应激和甘油三酯积累来逆转棕榈酸介导的胰岛素抗性
3. Metformin attenuates palmitic acid-induced insulin resistance in L6 cells through the AMP-activated protein kinase/sterol regulatory element-binding protein-1c pathway [J] . Wu Wenjun, Tang Sunyinyan, Shi Junfeng, International journal of molecular medicine . 2015,第6期

机译：二甲双胍通过AMP激活的蛋白激酶/固醇调节元件结合蛋白1c途径减弱L6细胞中棕榈酸诱导的胰岛素抵抗
4. Effects of retinoic acid-induced PKC-δ on the insulin like growth factor-I (IGF-I) system is involved in reactive oxygen species (ROS) in MCF-7 cells [C] . Young-Il Oh, Sang-Hoon Kim, Jong-Hoon Kim, International Conference on Biomedical Engineering and Informatics . 2008

机译：在MCF-7细胞中，转基金酸诱导的PKC-δ对胰岛素的影响，如生长因子-i（IGF-I）体系中的反应性氧物质（ROS）
5. The role of GLUT4 activation in glucose uptake: Potential implication for insulin resistance? [D] . Konrad, Daniel. 2003

机译：GLUT4激活在葡萄糖摄取中的作用：对胰岛素抵抗的潜在影响？
6. Lactiplantibacillus plantarum MG4296 and Lacticaseibacillus paracasei MG5012 Ameliorates Insulin Resistance in Palmitic Acid-Induced HepG2 Cells and High Fat Diet-Induced Mice [O] . Gayeong Won, Soo-Im Choi, Chang-Ho Kang, 2021

机译：Lactiplantibacillus plantarum mg4296和乳菌蛋白酶paracasei mg5012改善棕榈酸诱导的hepg2细胞和高脂肪饮食诱导的小鼠中的胰岛素抵抗力
7. Peer Review #1 of "Four sesquiterpene glycosides from loquat (Eriobotrya japonica) leaf ameliorates palmitic acid-induced insulin resistance and lipid accumulation in HepG2 Cells via AMPK signaling pathway (v0.2)" [O] . 2020

机译：同行评论“来自Loquat（Eriobotrya）叶中的”四个倍二萜糖苷来自枇杷（Eriobotrya）叶片通过AMPK信号通路（V0.2）“中的棕榈酸诱导的胰岛素抵抗和脂质积累。
8. Type-I Insulin-Like Growth Factor Receptor (IGF1R)-Estrogen Receptor (ER) Crosstalk Contributes to Antiestrogen Therapy Resistance in Breast Cancer Cells. [R] . Fagan, D. 2013

机译：I型胰岛素样生长因子受体（IGF1R） - 雌激素受体（ER）串扰有助于乳腺癌细胞中的抗雌激素治疗抗性。

Celastrol Reverses Palmitic Acid-Induced Insulin Resistance in HepG2 Cells via Restoring the miR-223 and GLUT4 Pathway

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