Clinical significance of personalized tacrolimus dosing by adjusting to donor CYP3A-status in liver transplant recipients

Csikany Nora; Kiss Adam; Deri Mate; Fekete Ferenc; Minus Annamaria; Toth Katalin; Temesvari Manna; Sarvary Eniko; Bihari Laszlo; Gerlei Zsuzsa; Kobori Laszlo; Monostory Katalin

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Clinical significance of personalized tacrolimus dosing by adjusting to donor CYP3A-status in liver transplant recipients

机译：个性化他克莫司给药在肝脏移植受者中的供体CYP3A状态调整的临床意义

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《British Journal of Clinical Pharmacology》 |2021年第4期|共11页
作者
Csikany Nora; Kiss Adam; Deri Mate; Fekete Ferenc; Minus Annamaria; Toth Katalin; Temesvari Manna; Sarvary Eniko; Bihari Laszlo; Gerlei Zsuzsa; Kobori Laszlo; Monostory Katalin;
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Res Ctr Nat Sci Inst Enzymol Budapest Hungary;

Res Ctr Nat Sci Inst Enzymol Budapest Hungary;

Res Ctr Nat Sci Inst Enzymol Budapest Hungary;

Res Ctr Nat Sci Inst Enzymol Budapest Hungary;

Res Ctr Nat Sci Inst Enzymol Budapest Hungary;

Res Ctr Nat Sci Inst Enzymol Budapest Hungary;

Res Ctr Nat Sci Inst Enzymol Budapest Hungary;

Semmelweis Univ Dept Transplantat &

Surg Budapest Hungary;

Semmelweis Univ Dept Transplantat &

Surg Budapest Hungary;

Semmelweis Univ Dept Transplantat &

Surg Budapest Hungary;

Semmelweis Univ Dept Transplantat &

Surg Budapest Hungary;

Res Ctr Nat Sci Inst Enzymol Budapest Hungary;

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原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
acute rejection; donor CYP3Aamp; 8208; status; infection; liver transplant recipients; nephrotoxicity; tacrolimus;

机译：急性排斥;捐赠CYP3A＆amp;8208;状态;感染;肝移植受者;肾毒性;他克莫司;

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专利

1. A retrospective analysis of the safety and efficacy of low dose tacrolimus (FK506) for living donor liver transplant recipients [J] . Zhengshan Wu, Qingyang Meng, Yongxiang Xia, 生物医学研究杂志（英文版） . 2013,第004期
2. A retrospective analysis of the safety and efficacy of low dose tacrolimus （FK506） for living donor liver transplant recipients [J] . Zhengshan Wu, Qingyang Meng, Yongxiang Xia, 生物医学研究杂志：英文版 . 2013,第004期
3. Clinical significance of personalized tacrolimus dosing by adjusting to donor CYP3A‐status in liver transplant recipients [J] . Nóra Csikány, ádám Kiss, Máté Déri, British journal of clinical pharmacology . 2021,第4期

机译：个性化他克莫司给药在肝脏移植受者中的供体CYP3A状态调整的临床意义
4. Personalizing initial calcineurin inhibitor dosing by adjusting to donor CYP3A-status in liver transplant patients [J] . Monostory Katalin, Toth Katalin, Kiss Adam, British Journal of Clinical Pharmacology . 2015,第6期

机译：通过调整肝移植患者的供体CYP3A状态来个性化初始钙调神经磷酸酶抑制剂的剂量
5. Differences in CYP3A genotypes of a liver transplant recipient and the donor liver graft and adjustment of tacrolimus dose [J] . Berger Florine A., Mulder Midas B., Bosch‐Dijksman Willemijn, British Journal of Clinical Pharmacology . 2019,第8期

机译：肝移植受体和供体肝移植的CYP3A基因型的差异及其调节曲粒剂剂量
6. Memetic Pareto Differential Evolutionary Neural Network for Donor-Recipient Matching in Liver Transplantation [C] . M. Cruz-Ramirez, C. Hervas-Martinez, P.A. Gutierrez, International work-conference on artificial neural networks;IWANN 2011 . 2011

机译：模因帕累托微分进化神经网络用于肝移植中供体-受体匹配
7. Neutropenic Enterocolitis in Adult Hematopoietic Stem Cell Transplant Recipients: Clinical characteristics and Prognostic Significance of Clinical Findings and Bowel Wall Thickening. [D] . Jimenez, Antonio M. 2012

机译：中性粒细胞性小肠结肠炎在成人造血干细胞移植受者中的临床特征及肠壁增厚的临床特征和预后意义。
8. Differences in CYP3A genotypes of a liver transplant recipient and the donor liver graft and adjustment of tacrolimus dose [O] . Florine A. Berger, Midas B. Mulder, Willemijn ten Bosch‐Dijksman, 2019

机译：肝移植受者和供体肝移植物中CYP3A基因型的差异和他克莫司剂量的调整
9. Personalized tacrolimus dose requirement by CYP3A5 but not ABCB1 or ACE genotyping in both recipient and donor after pediatric liver transplantation. [O] . Yi-kuan Chen, Long-zhi Han, Feng Xue, 2014

机译：小儿肝移植后CYp3a5个体化他克莫司剂量需求，但接受者和供者不接受aBCB1或aCE基因分型。
10. Recommendations for Premarket Notification (510(k)) Submissions for Nucleic Acid-Based Human Leukocyte Antigen (HLA) Test Kits Used for Matching of Donors and Recipients in Transfusion and Transplantation. Guidance for Industry. [R] . 2015

机译：上市前通知建议书（510（k））提交的基于核酸的人类白细胞抗原（HLa）测试试剂盒用于输血和移植中供体和受体的匹配。工业指南。

Clinical significance of personalized tacrolimus dosing by adjusting to donor CYP3A-status in liver transplant recipients

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