Streptozotocin-Induced Oxidative Stress in Rats: The Protective Role of Olive Leaf Extract

摘要

This paper investigates the antidiabetic and antioxidant effects of olive leaf extract(OLE)prepared in eth-anol upon Streptozotocin(STZ)-induced diabetic rats.The rats were divided into five groups(control,OLE,40 mg/kg STZ,0.25 g/kg OLE + STZ,and 0.5 g/kg OLE + STZ).The blood of rats was taken for determination of glucose levels besides oxidative activities(superoxide dismutase-SOD,glutathione per-oxidase-GPx,glutathione-S transferase-GST activities,and malondialdehyde-MDA)and biochemical parameters(alanine transaminase-ALT,aspartate transaminase-AST,and alkaline phosphatase-ALP).While ALP,AST,ALT,and MDA levels showed an increase,SOD,GPx,and GST levels decreased in Group STZ compared to Control Group.When compared to the group given only STZ,OLE played a significant role in decreasing MDA,ALT,AST,and ALP levels,apart from increasing GPx,and GST following treatment of diabetic rats.As a result,the in vivo data obtained have shown that the OLE has an antidiabetic effect thanks to restricting oxidative stress and reinforcing antioxidant activities.