Duloxetine and Subacute Pain after Knee Arthroplasty when Added to a Multimodal Analgesic Regimen A Randomized, Placebo-controlled, Triple-blinded Trial

摘要

Background: Duloxetine is effective for chronic musculoskeletal and neuropathic pain, but there are insufficient data to recommend the use of antidepressants for postoperative pain. The authors hypothesized that administration of duloxetine for 15 days would reduce pain with ambulation at 2 weeks after total knee arthroplasty.