Haloperidol Suppresses Murine Dendritic Cell Maturation and Priming of the T Helper 1-Type Immune Response

摘要

BACKGROUND: Haloperidol has immunomodulatory effects when used to treat patients with. schizophrenia and also is used to sedate critically ill patients in the intensive care unit. Although the mechanism by which haloperidol affects immune function is unclear, one possibility is that it alters dendritic cell (DC) function. DCs are potent antigen-presenting cells that influence the activation and maturation of T lymphocytes. In this study, we investigated the in vitro and in vivo immunomodulatory effects of haloperidol on DC-mediated immune responses.