Development of Unexploited Microbial Resources: Natural Products from Slime Molds

摘要

The muxomycetes (true slime molds) are an unusual group of primitive organisms that may be assigned to one of the lowest classes of eukaryotes. As their fruit bodies are very small and it is very difficult to collect much quantity of slime molds, few studies have been made on the chemistry of myxomycetes. Cultivation of the plasmodium of myxomycetes in a practical scale for natural products chemistry studies is known only for very limited species such as Physarum polycephalum. We recently studied the laboratory-cultivation of myxomycetes and several species have been successfully cultured in agar plates. Chemical constituents of cultured plasmodia of several species of myxomycetes of the genera Didymium and Physarum were examined to obtain several sterols, new lipid, or yrroloiminoquinone derivatives. Studies on the chemical constituents of the field-collected myxomycetes as well as synthetic studies of myxomycetes metabolites by other groups are also described here.