Acoustic (ultrasound) determination of concentration of whole protein and protein fractions in blood serum

摘要

A new method is suggested for determining the concentration of whole protein and the distribution of protein fractions in blood serum by means of an ultrasound device. The acoustic method is based on measuring the proliferation rate and absorption of the ultrasound signal in the examined serum. The findings of the method were compared with those obtained by routine tools in examining both blood sera of patients and controls. A high correlation factor was registered for the biuret method in the determination of the concentration of whole protein (R = 0.95; p < 0.05). It was demonstrated as possible to use the discussed method as a screening tool in evaluating the distribution of protein fractions. The examination findings are generated by the instrument as in the electrophoretic examination. The method is simple in use. No reagents are needed.