Novel Amino-Nicotinamide Derivatives as Modulators of KCNQ2/3 Potassium Channels

Gerard Rosse

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Novel Amino-Nicotinamide Derivatives as Modulators of KCNQ2/3 Potassium Channels

机译：新型氨基-烟酰胺衍生物作为KCNQ2 / 3钾通道的调节剂

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摘要

This invention provides a novel series of amino-nicotinamides which modulates the function of KCNQ2/3 potassium channels for the treatment and/or prophylaxis of pain.

机译：本发明提供了一系列新的氨基烟酰胺，其调节KCNQ2 / 3钾通道的功能以治疗和/或预防疼痛。

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《ACS medicinal chemistry letters》 |2013年第1期|共2页
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Gerard Rosse;
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正文语种 eng
中图分类药学;
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专利

1. Novel Amino-Nicotinamide Derivatives as Modulators of KCNQ2/3 Potassium Channels [J] . Gerard Rosse ACS medicinal chemistry letters . 2013,第1期

机译：新型氨基-烟酰胺衍生物作为KCNQ2 / 3钾通道的调节剂
2. Activation of KCNQ2/3 Potassium Channels by Novel Pyrazolo(1,5-a)pyrimidin-7(4H)-One Derivatives. [J] . Jia C, Qi J, Zhang F, Pharmacology: International Journal of Experimental and Clinical Pharmacology . 2011,第5a6期

机译：新型Pyrazolo（1,5-a）嘧啶7（4H）-One衍生物激活KCNQ2 / 3钾通道。
3. Expression of a calmodulin-binding KCNQ2 potassium channel fragment modulates neuronal M-current and membrane excitability. [J] . Shahidullah M, Santarelli LC, Wen H, Proceedings of the National Academy of Sciences of the United States of America . 2005,第45期

机译：钙调蛋白结合KCNQ2钾通道片段的表达调节神经元M流和膜兴奋性。
4. Interplay of potassium channels in modulating the action potential of the human left ventricle [C] . Wang C., Beyerlein P., Pospisil H., 2010 Computers in Cardiology . 2010

机译：钾通道在调节人类左心室动作电位中的相互作用
5. Interrogating K2P Pharmacology: Development and Characterization of Small-Molecule Modulators of Two-Pore Potassium Channels [D] . Pope, Lianne . 2019

机译：询问K2P药理学：两孔钾通道小分子调节剂的开发和表征
6. Discovery of a retigabine derivative that inhibits KCNQ2 potassium channels [O] . Hai-ning Hu, Ping-zheng Zhou, Fei Chen, 2013

机译：发现抑制KCNQ2钾通道的瑞替加滨衍生物
7. M-type KCNQ2–KCNQ3 potassium channels are modulated by the KCNE2 subunit [O] . Tinel Norbert, Diochot Sylvie, Lauritzen Inger, 2000

机译：M型KCNQ2-KCNQ3钾通道由KCNE2亚基调节

Novel Amino-Nicotinamide Derivatives as Modulators of KCNQ2/3 Potassium Channels

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