Phenolic glycosldes and other constituents from the bark of Magnolia officinalis

摘要

A new phenolic glycoside, syringic acid 4-O-Beta-D-glucopyranosyl-(l->5)-alpha-L-rhamnopyranoside (1), together with 12 known compounds consisting of eight phenolic glycosides (2-9), two phenolic acids (10 and 11), and two norsesquiterpe-noids (12 and 13), was isolated from the methanol extract of the bark of Magnolia officinalis. Their structures were elucidated on the basis of spectroscopic analysis and chemical methods. Compounds 1-11 were evaluated for their inhibitory activities against fructose-1,6-bisphosphatase, aldose reductase, lipase, dipeptidyl peptidase-IV, a-glucosidase, and three cancer cell lines. However, all the compounds showed weak or no activities in these tests.