Analysis of variability and antigenic peptide prediction of E2 BVDV glycoprotein in a mucosal-disease affected animal

摘要

Protein E2 of bovine viral diarrhoea virus (BVDV) is the immunodominant glycoprotein on the viral envelope and it is made up of about 370 amino acids. This protein is highly variable and it evokes a strong immune response including the production of neutralising antibodies; for this reason it was used to build a subunit vaccine that gives a good protection against the disease (Bolin and Ridpath, 1996).