Rationale and feasibility of mucin expression profiling by qRT-PCR as diagnostic biomarkers in cytology specimens of pancreatic cancer

Wiktorowicz Milosz; Mlynarski Damian; Pach Radoslaw; Tomaszewska Romana; Kulig Jan; Richter Piotr; Sierzega Marek

首页> 外文期刊>Pancreatology: official journal of the International Association of Pancreatology (IAP) ... [et al.] >Rationale and feasibility of mucin expression profiling by qRT-PCR as diagnostic biomarkers in cytology specimens of pancreatic cancer

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Rationale and feasibility of mucin expression profiling by qRT-PCR as diagnostic biomarkers in cytology specimens of pancreatic cancer

机译：QRT-PCR粘液表达谱的理由和可行性作为胰腺癌细胞学标本中的诊断生物标志物

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Background: Aberrantly expressed mucin glycoproteins (MUC) play important roles in pancreatic ductal adenocarcinoma (PDAC), yet their use as a diagnostic aid in fine-needle aspiration biopsy (FNAB) is poorly documented. The aim of this study was to investigate the rationale and feasibility of mucin (MUC1, MUC2, MUC3, MUC4, MUC5AC, and MUC6) expression profiling by RT-PCR for diagnostic applications in cytology.

机译：背景：异常表达的粘蛋白糖蛋白（MUC）在胰腺导管腺癌（PDAC）中起重要作用，但它们作为细针吸入活检（FNAB）的诊断助剂的用途记录不佳。本研究的目的是探讨粘蛋白（MUC1，MUC2，MUC3，MUC4，MUC5AC和MUC6）表达分析对细胞学诊断应用的理由和可行性。

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来源
《Pancreatology: official journal of the International Association of Pancreatology (IAP) ... [et al.]》 |2018年第8期|共6页
作者
Wiktorowicz Milosz; Mlynarski Damian; Pach Radoslaw; Tomaszewska Romana; Kulig Jan; Richter Piotr; Sierzega Marek;
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作者单位

Jagiellonian Univ Dept Surg 1 Med Coll Krakow Poland;

Jagiellonian Univ Dept Pathol Med Coll Krakow Poland;

Jagiellonian Univ Dept Surg 1 Med Coll Krakow Poland;

Jagiellonian Univ Dept Pathol Med Coll Krakow Poland;

Jagiellonian Univ Dept Surg 1 Med Coll Krakow Poland;

Jagiellonian Univ Dept Surg 1 Med Coll Krakow Poland;

Jagiellonian Univ Dept Surg 1 Med Coll Krakow Poland;

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正文语种 eng
中图分类消化系及腹部疾病;
关键词
Pancreatic cancer; Chronic pancreatitis; Mucins; Diagnosis; Fine needle aspiration biopsy;

机译：胰腺癌;慢性胰腺炎;粘蛋白;诊断;细针穿刺活检;

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1. Rationale and feasibility of mucin expression profiling by qRT-PCR as diagnostic biomarkers in cytology specimens of pancreatic cancer [J] . Wiktorowicz Milosz, Mlynarski Damian, Pach Radoslaw, Nature reviews Cancer . 2018,第8期

机译：QRT-PCR粘液表达分析的理由和可行性作为胰腺癌细胞学标本诊断生物标志物
2. Tissue MicroRNA profiles as diagnostic and prognostic biomarkers in patients with resectable pancreatic ductal adenocarcinoma and periampullary cancers [J] . Dan Calatayud, Christian Dehlendorff, Mogens K. Boisen, Biomarker Research . 2017,第1期

机译：组织MicroRNA谱作为可切除的胰腺导管腺癌和壶腹周围癌患者的诊断和预后生物标志物
3. S100P and XIAP Expression in Pancreatic Ductal Adenocarcinoma: Potential Novel Biomarkers as a Diagnostic Adjunct to Fine Needle Aspiration Cytology. [J] . Kosarac O, Takei H, Zhai QJ, Acta Cytologica: The Journal of Clinical Cytology and Cytopathology . 2011,第2期

机译：S100P和XIAP在胰腺导管腺癌中的表达：潜在的新型生物标志物作为细针穿刺细胞学诊断的辅助手段。
4. Computer aided cytological cancer diagnosis: Cell type classification as a step towards fully automatic cancer diagnostics on cytopathological specimens of serous effusions [C] . Timna E. Schneider, Andre A. Bell, Dietrich Meyer-Ebrecht, Computer-Aided Diagnosis pt.1; Progress in Biomedical Optics and Imaging; vol.8,no.33; Proceedings of SPIE-The International Society for Optical Engineering; vol.6514 pt.1 . 2007

机译：计算机辅助细胞学癌症诊断：将细胞类型分类作为对浆液积液的细胞病理学标本进行全自动癌症诊断的步骤
5. Characterization of rhabdomyosarcoma, breast, and pancreatic cancer by expression profiling, and, Roles of fibulin-2 and MUC1 in breast and pancreatic cancer [D] . Yi, Chunhui. 2006

机译：通过表达谱分析横纹肌肉瘤，乳腺癌和胰腺癌的特征，以及fibulin-2和MUC1在乳腺癌和胰腺癌中的作用
6. MicroRNA expression profiling of diagnostic needle aspirates from surgical pancreatic cancer specimens [O] . Tae Ho Hong, Il Young Park 2014

机译：手术胰腺癌标本中诊断针吸出物的MicroRNA表达谱
7. MicroRNA expression profiling of diagnostic needle aspirates from surgical pancreatic cancer specimens [O] . Tae Ho Hong, Il Young Park 2014

机译：来自外科胰腺癌标本的诊断针吸气的MicroRNA表达谱

Rationale and feasibility of mucin expression profiling by qRT-PCR as diagnostic biomarkers in cytology specimens of pancreatic cancer

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