Studying Interrelation of PDLIM4 with the Model of CD74-Mediated Development of Breast Cancer

摘要

Mammary gland tumors are often characterized by deregulation of RIL/PDLIM4 expression, however, PDLIM4-mediated mechanisms of cancer development still remain unknown. The aim of our research was to study the influence of PDLIM4-deregulation on transcript me changes of malignized cells. We performed a comparative NGS-analysis of breast cancer cell lines with suppressed and induced expression of PDLIM4 and identified a number of genes, whose expression correlated with PDLIM4 level. Among them we foundCD74 gene, which is known as a potential marker of triple negative subtype of breast cancer. The obtained results allowed us to propose an interrelation between PDLIM4 and the CD74-mediated mechanism of breast cancer development and to analyze the correlation of PDLIM4 with the main components of CD-74-dependent model.