One Pot, Simple, and Efficient Synthesis of 2-Azetidinones Mediated by 3-(Diethoxyphosphoryloxy)-1,2,3-benzotriazin-4-(3H)-one

摘要

Background: 2-Azetidinones (beta-lactams) has occupied an important role in organic chemistry and drugs. beta-Lactam antibiotics are extensively applied to fight against microorganisms as antibiotic drugs. The Staudinger's ketene-imine cycloaddition is one of the most common approaches in the synthesis of 2-azetidinones. The aim of this paper to describe a methodology based on the use of 3( diethoxyphosphoryloxy)-1,2,3-benzotriazin-4-(3H)-one (DEPBT) for the synthesis of 2-azetidinones under mild reaction conditions at room temperature.