A randomized placebo-controlled trial of progesterone with or without hypothermia in patients with acute severe traumatic brain injury

摘要

Objective: Among newer neuroprotectant modalities, hypothermia and progesterone have shown a beneficial role in preliminary studies enrolling patients with severe traumatic brain injury (sTBI). The primary objective of this study was to evaluate the efficacy of progesterone with or without prophylactic hypothermia in acute sTBI patients.